antithrombin i การใช้

• Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids.
• The heparin pentasaccharide-bound form of antithrombin is, thus, a more effective inhibitor of thrombin and factor Xa.
• Antithrombin I ( AT I ) refers to the absorption of thrombin onto fibrin after thrombin has activated fibrinogen . plasma that inactivates thrombin.
• Antithrombin is approved by the FDA as an anticoagulant for the prevention of clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency.
• In kidney failure, especially nephrotic syndrome, antithrombin is lost in the urine, leading to a higher activity of Factor II and Factor X and in increased tendency to thrombosis.
• It contains three disulfide bonds and a total of four possible glycosylation sites . ?-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites.
• Even though it is present at only 5 10 % the levels of ?-antithrombin, due to its increased heparin affinity, it is thought that ?-antithrombin is more important than ?-antithrombin in controlling thrombogenic events resulting from tissue injury.